The dominant rationale to generate new (and to assess old) anticancer chemotherapeutic agents is to determine their cell-autonomous effects — that is, their capacity to reduce the growth ...

Golgi phosphoprotein 73 (GP73, also termed as GOLM1 or GOLPH2) is a glycosylated protein residing on cis-Golgi cisternae and highly expressed in various types of cancer tissues. Since GP73 is a ...

NLRP3 can be activated in response to extracellular ATP and K + efflux through the ATP-gated P2X7 channel, in response to cathepsin B release from damaged lysosomes or in response to reactive oxygen ...

Their shape varies depending on the developmental and functional state, and anatomical location. Caspases are known to mediate neuronal apoptosis during brain development. Here authors demonstrate ...