The MTOR pathway is built up by signaling via its two sub-complexes, MTORC1 and MTORC2, and each has its own unique regulatory mechanisms. The proteins of interest in this project are involved in the ...

Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

However, anti-inflammatory mechanisms targeting IL-1β release in cardiac cells have not been investigated. mTOR is a key regulator of protein metabolism, including autophagy and proteasome activity.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The oncogenic mechanisms by which TFE3 fusion ...

Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles ...

National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, ...

牙周炎（Periodontitis）是一种常见的口腔慢性炎症性疾病，是成人牙齿脱落的原因之一。已有研究表明，牙周炎的发生与巨自噬/自噬（Macroautophagy/autophagy）过程有着复杂的联系，自噬像一把双刃剑，在维持牙周稳态中起到双重作 ...