Non-genetic drug adaptation to MAPK pathway inhibitors in melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr ...

阿尔茨海默病（AD）临床治疗效果不佳。p38MAPK参与 AD 发病机制，针对 MAPK 的研究尝试探究其对记忆等的影响。相关 MAPK 抑制剂临床试验有积极成果，但存在问题。本文聚焦 MAPK 干预疗法治疗 AD 的临床研究，值得关注。 阿尔茨海默病现状 阿尔茨海默病（AD ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

(Nasdaq: ERAS), a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-d Potentially best-in ...

The complex interplay between different components of the MAPK pathway, including KRAS, BRAF, CRAF, their regulators, and downstream effectors, has led to new insights into resistance mechanisms and ...

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DELFI Diagnostics, Inc., developer of innovative blood-based tests that leverage cell-free DNA (cfDNA) fragmentomics for cancer detection and monitoring, today announced its team is presenting at the ...

Get Instant Summarized Text (Gist) Low levels of the enzyme GPT1 significantly influence the progression of colorectal cancer (CRC) by promoting tumorigenesis through metabolic reprogramming. GPT1 ...

Simultaneously targeting lysosomal enzyme and KRAS-MAPK pathway eradicates pancreatic tumors in preclinical models 29 minutes ago Exercise boosts brain health—even when energy is low ...