Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...

Glioblastoma is the most aggressive and most common malignant brain cancer in adults. It is currently treated with surgery, followed by radiation and chemotherapy. The prognosis is poor even with ...

These proteins, called MDM2 and MDMX, become overactive in cancer and break down p53. Researchers have developed drugs to block MDM2 or MDMX, but targeting just one of these proteins is often not ...

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Cyclin E is recruited to the centrosome via its centrosome localization domain to promote entry into the S phase and facilitate centriole duplication. It is bound to both the centrosome and its Cyclin ...

These findings underscore the complex relationship between FRGs and MDS (Zhu et al., 2024). In an alternate study, another group of FRGs (BNIP3, MDM2, and RRM2) were demonstrated to serve as ...

This study provides important computational insights into the dynamics of PROTAC-induced degradation complexes, offering a convincing demonstration that differences in degradation efficacy can be ...

Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno 602 00, Czech Republic ...