The DREAM complex is a transcriptional repressor whose expression is regulated indirectly via p53-mediated induction of the CDK inhibitor p21. Here, p53 is found to directly regulate DREAM complex ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Oscillatory p53 expression occurs in ...

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PI3K 抑制剂能否解乳腺癌内分泌治疗耐药的燃眉之急？以 PI3K 抑制剂为基础的联合治疗对于内分泌耐药人群的治疗前景如何？本文中，笔者与您一同来探讨这些问题，旨在为临床诊疗提供思路与启发。

This figure from Zafar et al. (2020) highlights key molecular signaling pathways, genomic targets, and molecular targets implicated in neuroblastoma, emphasizing the complex network of dysregulated ...

In this article, García-Vázquez et al. report valuable findings demonstrating that G2 and S phases expressed protein 1 (GTSE1), is a previously unappreciated non-pocket substrate of the cyclin ...

CDK2 binds to its cyclin partner (cyclin E) but this interaction is inhibited by p21, the latter which gets activated by p53. Centriole duplication and elongation commences in ... It is bound to both ...

肿瘤的研究一直是生命科学和基础医学领域中的热门话题，随着分子生物学和肿瘤生物学等学科的发展，人们逐渐明确了一系列与肿瘤发生和转移等 ...