Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

This repository provides means of adding Lumigo tracing as "infrastructure-as-code" to Lambda functions and ECS workloads deployed via the AWS Cloud Development Kit (CDK) v2.

1Department of Experimental Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China; ...

结果表明 CCT8 在 CRC 中显著上调，通过 RPL4-MDM2-p53 轴促进肿瘤进展。该研究为 CRC 治疗提供新方向。 结直肠癌，这个 “健康杀手” 在全球范围内肆意横行，每年都无情地夺走无数人的生命。它就像一个隐藏在暗处的恶魔，早期症状不明显，许多患者确诊时往往已 ...

This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of ...

卵巢癌（OC）铂耐药是临床难题，卵巢透明细胞癌（OCCC）尤为突出。研究人员开展了关于糖原对 OCCC 铂耐药影响的研究，发现 GYS1 与 OCCC 预后及化疗耐药相关，揭示了 p53/GYS1 反馈回路促铂耐药机制，为攻克 OCCC 铂耐药提供新方向。 卵巢癌（OC）是一种致命且难治 ...