This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...

Here, a degree is a pursuit of purpose where learning empowers you, well-being strengthens you and an experience-driven education leads to a meaningful career. Western is the place to become your best ...

Mechanistically the combination of these two agents decreased the expression of MDM2, without affecting p53 activation or its expression. Therefore, this short study provides the foundation to ...

Western Blot（蛋白免疫印迹）是分子生物学中检测特定蛋白表达的“金标准”，但其复杂的步骤和细节常让新手头疼。本文将从原理、实验步骤、常见问题及解决方案三方面入手，带你彻底掌握这项技术！ SDS（十二烷基硫酸钠）使蛋白带负电荷，消除形状差异 ...

Design Proteomics analysis, qPCR and western blotting were used to screen for hTERT-regulated candidate molecules in ... Importantly, FOXO3a played a major role in hTERT-induced ITGB1 expression, and ...

在癌症研究领域，癌细胞应对内质网（ER）应激的机制尚不明晰。为探究此问题，研究人员以结肠癌为研究对象，聚焦 mutant p53（mutp53）。研究发现 mutp53 通过上调 HDAC6，维持 Ku70 水平，减轻 ER 应激诱导的 DNA 损伤。该成果为攻克 mutp53 相关癌症提供新方向。

And in particular, some of the very founding ideas of the West—the Christian faith on which all Western nations were in some important respect really based on in their original charter—those ...

MDM2 是负调节 p53 的 E3 泛素连接酶 ... 添加 erastin 进一步破坏类器官形态，而添加 ferrostatin - 1 则可挽救。Western blot 和免疫组化染色显示，FTD/TPI 增加了 CRC 类器官细胞中 p53 蛋白水平，降低了 SLC7A11 水平。添加 SAS 显著抑制了 9 例患者来源类器官的活力，联合 ...

No one wishes for their meticulously crafted look to be spoiled by surplus oil. Consequently, oil blotting sheets can be a game-changer. Created to soak up additional skin oil, these convenient ...