黑色素瘤预后不佳，现有疗法存在耐药问题。研究人员探究蛋白酶体抑制剂 MG132 对黑色素瘤 A375 细胞的作用。发现 MG132 能抑制细胞增殖、迁移并诱导凋亡，其机制与 MDM2、p53 等相关。为黑色素瘤治疗提供新思路。 在癌症的众多类型中，黑色素瘤是一种极具侵略 ...

Galvanic vestibular stimulation (GVS) involves applying small electrical currents to the vestibular organs via electrodes placed on the mastoids, providing a powerful tool for investigating vestibular ...

The non-structural protein nsp16 of SARS-CoV-2 was identified that can be degraded through the proteasome pathway. A. The non-structural proteins nsp8, nsp11 and nsp16 could be restored by the ...

In healthy cells, cyclin D1 is expressed during the G1 phase of the cell cycle, where it activates CDK4 and CDK6. Its dysregulation is a well-established oncogenic driver in numerous human cancers.

常见的糖尿病（如 1型糖尿病、2型糖尿病）在OGTT实验时，往往具有更高的血糖增量 >3mmol/L； 而大多数 （67%） 单基因糖尿病 HNF1A-MODY 和 HNF4A-MODY 的人 ...

Researchers have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome.