we engineered oncolytic viruses co-expressing neoantigens and neoantigen-binding major histocompatibility complex (MHC) molecules to force ectopic delivery of peptide-MHC ligands to T cell receptors ...

Importantly, an antigenic peptide derived from the reverse strand of two cDNA constructs was presented on MHC-I molecules and induced CD8 + T cell activation. The results demonstrate that three-frame ...

The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell ...

Miliotis, a member of the Pharmaceutical Sciences and Pharmacogenomics (PSPG) Graduate Program, continued her dating analogy, explaining that Major Histocompatibility Complex molecules (MHCs), which ...

Since TP conjugation is restricted to peptides, this requires the identification and characterization of immunogenic T cell epitopes and their corresponding MHC molecules. The direct delivery of ...

Lip balms and chapsticks have always been skincare staples, but thanks to the rise of peptide lip balms, they've gone from basic hydration heroes to beauty must-haves. Hailey Beiber's launching of the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In response to infections, naive CD8 T cells ...

Arthritogenicity was investigated by passive transfer experiments. Antigen-specific B cells were identified by peptide tetramer staining. Conclusions We have identified the major pathogenic B cell ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

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