A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages.

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components ...

The team from Israel, the US, and China has developed a genetic method to reprogramme a type of immune cell, turning them ...

Building on grounding-breaking research into the immuno-suppressive role of tumor-associated macrophages (TAMs), Macomics has developed a unique platform, ENIGMAC combining a human bioinformatic ...

Richard Staines spoke with Soren Bregenholt, the new CEO of Macrophage Pharma, about the company’s strategy encompassing both immune oncology and inflammatory diseases. In healthy tissues ...

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health ...

Researchers discovered that EBV infection triggers macrophage pyroptosis—a form of inflammatory cell death—by accelerating glycolysis, a key metabolic pathway. This cascade of events worsens ...

Through CRISPR-Cas9 gene editing and single-cell analysis, they zeroed in on a gene named Zeb2.