Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

The researchers found that Zeb2 acts as a master switch. When the gene is active, it turns macrophages into cancer supporters ...

The researchers found that Zeb2 acts as a master switch. When the gene is active, it turns macrophages into cancer supporters. When silenced, macrophages revert to their natural, cancer-fighting role.

Through CRISPR-Cas9 gene editing and single-cell analysis, they zeroed in on a gene named Zeb2.

Macrophages, part of the innate immune system, can exhibit a form of immune memory by adjusting their molecular signaling after an infection. This adaptation can either enhance or reduce their ...

Carisma Therapeutics is developing a unique, differentiated immuno-oncology (IO) treatment for solid tumors based on chimeric antigen receptor macrophages (CAR-M). Current IO treatments have ...

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health ...