Macrophage infiltration in various solid tumors is associated with poor prognosis ... LA-TAMs express characteristic genes involved in lipid metabolism, ECM degradation, and complement activation.

In turn, immune cells could directly or indirectly dictate ECM through the production of cytokines and chemokines (e.g., TGF-b, IL-13, CXCL4). For example, macrophages are pivotal in ECM remodeling ...

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To evaluate spatial and temporal changes in the ECM structure and gene expression, tissue samples were collected at 1 day, 3 weeks, and 6 weeks after bleomycin and epithelial disruption. Data analyses ...

The researchers also discovered that when these cells, called macrophages, eat live bacteria it triggers an inflammation response. But when they eat dead bacteria it doesn't. "When phagocytic ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Using single-cell transcriptomics, they tracked dynamic changes in various cell types, including monocytes, macrophages ... and disruption of the ECM. To address these issues, the researchers ...

One approach is to add bioactive components to ligament scaffolds. For instance, adding ECM components like hyaluronic acid and collagen can enhance cell adhesion and proliferation. Another ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical ...