Representative images in selected time points are shown (right). Arrows denote phagocytic macrophages. Trained or control macrophages were pre-stained with CFSE and were then co-cultured with ...

Macrophage phagocytosis has been implicated in regulating anti-tumour immunity. Trained innate immunity (TII), induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates ...

Innate immunity is an immunological subsystem that comprises the cells and mechanisms that provide the first line of defence from infection in a non-specific manner. Innate immune responses are ...

Additionally, this review discusses the role of LPS as an environmental substance in maintaining homeostasis in individuals via the mucosal membrane and the macrophage network hypothesis. 2 ...

Macrophages play a crucial role in the tumor microenvironment (TME), exhibiting ... Alejandro Villagra. Selective HDAC10 inhibitor enhances innate antitumor immunity [abstract]. In: Proceedings of the ...

Macrophages are ubiquitous innate immune cells found in almost every organ of the body ... These properties of FimH were then validated in human macrophages and were shown to have therapeutic ...

REDWOOD CITY, CA, USA I April 14, 2025 I Pheast Therapeutics, a private biotechnology company developing novel therapies to unleash the power of macrophages ...

Pheast Therapeutics has treated the first patient in a phase 1 trial of PHST001, a novel macrophage checkpoint inhibitor for advanced solid tumors.

University of Chicago, Chicago, IL.

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