Medulloblastoma (MB) is the most common malignant pediatric brain tumor and is derived from neuroepithelial stem cells (NESC). Amplification of each member of the MYC family of oncogenes (MYCN, CMYC, ...

They discovered a novel line of communication between metastatic medulloblastoma and leptomeningeal fibroblasts that mediates recruitment and reprogramming of the latter to support tumor growth.

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth. Nature Cell Biology , 2025; DOI: 10.1038/s41556-025-01660-7 ...

making clinical development of MYC inhibitors challenging. MYCN amplification and overexpression generate driver signals in the childhood cancers, neuroblastoma (NB), medulloblastoma (MB) and diffuse ...

They discovered a novel line of communication between metastatic medulloblastoma and leptomeningeal fibroblasts that mediates recruitment and reprogramming of the latter to support tumor growth.

Researchers at Baylor College of Medicine, Texas Children’s Hospital, the Hospital for Sick Children in Toronto and collaborating institutions reveal in Nature Cell Biology a strategy that helps ...

Researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions reveal in Nature Cell Biology a strategy that helps ...

Researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions reveal in Nature Cell Biology a strategy that helps ...

结果发现 SNORA47 与预后、TNM 分期相关，通过 EBF3/RPL11/c-Myc 轴影响干性和化疗敏感性，为治疗提供新靶点。 在女性健康的 “战场” 上，乳腺癌可谓是头号 “劲敌”。全球范围内，它是女性中极为常见的恶性肿瘤，严重威胁着女性的身心健康。乳腺癌可不是个 ...