CURE spoke with John Crispino, the director of the division of experimental hematology at St. Jude Children’s Research Hospital.

Future Microbiol. 2013;8(11):1431-1451. Platelet GPIIIa, and even the same epitope within this surface protein, are also targets of autoantibodies, which are generated in HIV-infected patients.

Abstract and Introduction Review of Normal Platelet Physiology and Megakaryocytopoisis Qualitative Platelet Abnormalities Conclusion References ...

ITP has more complex pathophysiological features that involve rapid phagocytosis of IgG autoantibody-coated platelets in the spleen and liver and autoantibody-mediated damage to megakaryocytes ...

At no time was thrombocytopenia noted, nor did the platelet count rise after splenectomy ... The erythroid series was normal, and megakaryocytes were adequate. Scattered mature lymphocytes ...

Lymphocytes are a type of white blood cell produced in bone marrow that play a crucial role in your immune system. There are several types—called T cells, B cells, and natural killer (NK) cells—that ...