Specifically, we demonstrate how PI3Kγ signalling restricts inflammatory macrophages and that inhibition supports MERTK-dependent efferocytosis. We further find that the combination of PI3Kγ ...

Western blot and flow cytometry were also employed to evaluate the protein expression of specific genes. Results: In patients with NPDR compared to those with DM alone, MerTK—a gene implicated in ...

"We sought to identify alternative ways to inhibit TGFβ signaling using human hepatic stellate cells and macrophages from ... levels of an enzyme known as MERTK. They also found that liver ...

Current studies pictured the enteric nervous system and macrophages as modulators of neuroimmune processes in the inflamed gut. Expanding this view, we investigated the impact of enteric ...

1 Non-Coding RNA and Cancer Biology Laboratory, Department of Zoology, Central University of Punjab, Bathinda, India 2 Amity Centre for Translational Research, Amity University, Noida, India ...

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

Metabolomic analysis confirms a reduction in SAM level upon AurA inhibition. As a result of SAM deficiency, trained mouse macrophages exhibit decreased H3K4me3 and H3K36me3 enrichment on gene regions ...

However, neutrophil, basophil, and programmed death ligand 2 (PD-L2 +) monocyte/macrophage levels did not differ between the groups. This finding implies that restraint stress leads to ...

From the Center for Systems Biology (W.C.P., M.N., F.K.S.), Massachusetts General Hospital and Harvard Medical School, Boston. From the Center for Systems Biology (W ...

Objective Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of ...