The metabotropic glutamate receptors (mGluRs) are found throughout the central nervous system, where they modulate neuronal excitability and synaptic transmission. Here we report the presence of ...

The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the ...

For most of us, getting less than seven hours of sleep translates into grogginess, sluggish thinking, and an overwhelming urge to crawl back into bed. But some people wake up fresh and energized after ...

The findings point the way to treatment options targeting group 1 metabotropic glutamate receptors. This study is a major step toward the ultimate goal of treating fragile X syndrome (FXS), an ...

a novel orally active metabotropic glutamate receptor subtype 2 positive allosteric modulator (mGlu2 PAM) for the treatment of epilepsy; and GABAB PAM for the treatment of pain, anxiety ...

在这样的背景下，来自伊朗的研究人员展开了探索。他们把目光聚焦在褪黑素（melatonin）上，这是一种具有强大神经保护功能的神经激素，在 AD 患者体内含量明显降低，而且和记忆受损程度密切相关。研究人员想知道，褪黑素能否成为对抗 AD 的 “秘密武器” 呢？这项研究成果发表在了《Behavioral and Brain Functions》杂志上。

and it will also work on a metabotropic glutamate receptor subtype 7 negative allosteric modulator (NAM). Both are in preclinical development. Other companies working on PAMs include Cerevel ...

ionotropic and metabotropic, and different second messenger systems). Using promiscuity maps to guide drug discovery could proceed as follows. First, a drug-centric promiscuity map akin to that ...

The study specifically examines two types of GPCRs expressed on astrocytes: dopamine D1 receptors (D1R) and metabotropic glutamate receptor 5 (mGLUR5). These receptors respond to various ligands, ...

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative affect, and ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G ...