By engineering human immune cells called microglia, the researchers have created living cellular "couriers" capable of responding to brain pathology and releasing therapeutic agents exactly where ...

Summary: Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic proteins precisely where needed. Using CRISPR technology, the team ...

Microglia are a type of small macrophage-like glial cell in the central nervous system. Microglia can engage in phagocytosis, and are involved in immune responses within, as well as the ...

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

By engineering human immune cells called microglia, the researchers have created living cellular “couriers” capable of responding to brain pathology and releasing therapeutic agents exactly where ...

Following ischemic white matter damage, microglia are responsible for phagocytosing and degrading cholesterol-rich myelin debris, storing them as lipid droplets. However, our understanding of how ...

By engineering human immune cells called microglia, the researchers have created living cellular “couriers” capable of responding to brain pathology and releasing therapeutic agents exactly ...

By engineering human immune cells called microglia, the researchers have created living cellular "couriers" capable of responding to brain pathology and releasing therapeutic agents exactly where ...

They did this by turning stem cells — which can become any cell in the body — into brain immune cells called microglia. The edited cells were able to clear the junk without harming healthy ...

The research team at the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences confirmed the existence of microglia — a type of immune cellin the peripheral nervous ...

The study, published in Brain, Behavior, and Immunity, focused on microglia—immune cells that help protect the brain. These cells have receptors called β2AR that allow them to respond to ...