By engineering human immune cells called microglia, the researchers have created living cellular "couriers" capable of responding to brain pathology and releasing therapeutic agents exactly where ...

Summary: Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic proteins precisely where needed. Using CRISPR technology, the team ...

Li Hanjie from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the presence of microglia in the peripheral nervous system (PNS) and identified ...

By engineering human immune cells called microglia, the researchers have created living cellular “couriers” capable of responding to brain pathology and releasing therapeutic agents exactly where ...

Following ischemic white matter damage, microglia are responsible for phagocytosing and degrading cholesterol-rich myelin debris, storing them as lipid droplets. However, our understanding of how ...

In a study published in Cell on April 7, a research team led by Prof. LI Hanjie from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the presence ...

Background Autophagy has emerged as a critical homeostatic mechanism in T lymphocytes, influencing proliferation and differentiation. Autophagy in B cells has been less studied, but genetic deficiency ...

SHENZHEN -- Chinese scientists have, for the first time, confirmed the existence of microglia in the peripheral nervous system (PNS). This breakthrough provides novel insights into PNS development ...

This important work advances our understanding of the aging trajectory and heterogeneity of hippocampal microglia. The authors provide an in-depth characterization of microglia in young and old mice ...