All subjects underwent Doppler echocardiography. Twenty-one percent of subjects had mild diastolic dysfunction, and 7% had moderate-to-severe diastolic dysfunction; only a quarter of those with ...

Risk for incident stroke and transient ischemic attack, as well as major bleeding, is affected by severity of left ventricular diastolic dysfunction. An independent association exists between left ...

Community-based studies revealed a higher prevalence of LV systolic and diastolic dysfunction using the new echocardiographic imaging techniques. Future prospective studies will clarify the ...

In patients with HF and preserved ejection fraction (HFpEF), LV ejection fraction is normal, although contractile dysfunction is often present and only detected with advanced imaging techniques.

They are of limited use because they do not account for pulmonary flow. A TPDG >7 mmHg predicted RVF after LVAD implantation in a single study (100). Right ventricle diastolic dysfunction cannot be ...

JK-07 is under clinical development by Salubris Biotherapeutics and currently in Phase II for Diastolic Heart Failure (HFpEF). According to GlobalData, Phase II drugs for Diastolic Heart Failure ...

Ziltivekimab is under clinical development by Novo Nordisk and currently in Phase III for Diastolic Heart Failure (HFpEF). According to GlobalData, Phase III drugs for Diastolic Heart Failure (HFpEF) ...

Correspondence to Dr Martin Penicka, Department of Cardiology, Cardiovascular Center, Moorselbaan 164, Aalst 9300, Belgium; Martin.Penicka{at}olvz-aalst.be ...

Heart failure with preserved ejection fraction (HFpEF) looms as a major public heart challenge with increasing prevalence due to an ageing population. Diagnosis can be challenging due to non-specific ...

"ALPK2-overexpression suppressed progression of diastolic dysfunction. In addition, it improved lung weight, which is often used as an index of heart failure," Yoshida summarized. "HFpEF is a ...