Precursor proteins are unfolded and imported into mitochondria by a macromolecular machine that spans two membranes and contains at least nine different proteins. Here we examine import of a model ...

肥胖已成为全球公共卫生危机，影响约6.5亿人口，并显著增加心血管代谢疾病和癌症风险。 据《每日科技网》（scitechdaily）报道，近期研究发现，抑制粒线体蛋白MCJ （Mitochondrial protein MCJ）可提升棕色脂肪活性 ...

A new study uncovers a novel mechanism through which brown fat is transformed into heat, offering protection against ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

Researchers have identified a mechanism where the removal of the mitochondrial protein MCJ in mice leads to increased heat ...

There are several mechanisms involved. The newly reported research has uncovered one mechanism, which they found is controlled by the mitochondrial protein MCJ. The researchers first identified ...

Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health. "Based on our discoveries, targeting insoluble proteins ...

Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been ...

Mitochondria organelles came from primordial bacterial endosymbionts and still preserve distinct genes for important functions like making ATP. To speed the emerging therapeutic research into the ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death.