Precursor proteins are unfolded and imported into mitochondria by a macromolecular machine that spans two membranes and contains at least nine different proteins. Here we examine import of a model ...

A new study uncovers a novel mechanism through which brown fat is transformed into heat, offering protection against ...

However, it has also been reported to be able to enhance protein stability and regulate protein activities. Ubiquitination plays an essential role in maintaining normal mitochondrial functions.

Researchers have identified a mechanism where the removal of the mitochondrial protein MCJ in mice leads to increased heat ...

There are several mechanisms involved. The newly reported research has uncovered one mechanism, which they found is controlled by the mitochondrial protein MCJ. The researchers first identified ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of ...

Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, United States ...

Most animal, plant and fungal cells contain organelles called mitochondria. These descendants of a primordial bacterial ...

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen ...