[1] Ohren J F, Chen H, Pavlovsky A, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition [J]. Nature Structural & Molecular Biology, 2004, 11 ...

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Here, the kinase partners with TOM and VDAC, forming a supersized complex that tethers PINK1 to the outer membrane—a crucial first step toward clearing these defective organelles. The study appeared ...

Efforts are focused on an enzyme known as p38 MAP kinase, which is a “master regulator” of production of IL-10. As well as blocking IL-10, inhibiting p38 MAP kinase also restores levels of ...

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Elevation of the proinflammatory cytokine Interleukin-1 (IL-1) is an integral part of the local tissue reaction to central nervous system (CNS) insult. The discovery of increased IL-1 levels in ...

2 GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Correspondence to Loes E M Kistemaker, Department of Molecular Pharmacology, ...