The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, United States Here, we combined mouse genetics and in vitro axon guidance assays to revisit the functions of ...

The study is well done and convincingly demonstrates the role of Sp1 in motor neuron axon guidance. Further discussion and clarification of some results would further improve the study. (1) The ...

Neurons are cells in the body that are responsible for transmitting electrical signals through the nervous system. Different types of neurons affect the ability to move, which begins as an impulse, or ...

Every soft caress of wind, searing burn and seismic rumble is detected by our skin’s tangle of touch sensors. David Ginty has ...

An evolutionarily conserved micropeptide, Sertm2, encoded by the lncRNA A730046J19Rik, promotes Etv4 + motor neuron subtype specification by GDNF, proper neurite development, and motor function.

The three neuron types (sensory, motor, interneuron ... more quickly than the unmyelinated nerves in the body. Myelinated ...

Each type of motor neurone disease affects different parts of the body, particularly during the early stages of the condition. ALS, which is the most common type, initially causes muscle weakness ...

The US actor, who was also in Grey's Anatomy, has the most common form of motor neurone disease. Half of the proceeds from Anita Newton's book will go to the Motor Neurone Disease Association.

It’s the diagnosis that everyone dreads. Motor neurone disease (MND) is a progressive and, as yet, incurable illness that results in gradual paralysis and death, almost certainly within one to ...

Objective: To determine the pattern of motor neurone loss in amyotrophic lateral sclerosis (ALS). In particular, to determine whether there is a gradual life long presymptomatic motor neurone loss or, ...