but also in a humanized mouse model with cells from PSC patients, which indicates that this effect could also work in the human intestine." This study provided new mechanistic insights into the ...

examined the effects of bile acids on energy expenditure in mice, and in cultured mouse and human cells. The team found that administering cholic acid—a bile acid—to mice on a high-fat diet ...

We have, therefore, developed a BAAT knockout mouse in our lab that lacks these taurine- and glycine-conjugated bile acids. By introducing MCBAs to the guts of these BAAT knockout mice ...

while the bile acid that inhibits FXR acts as fuel for the tumors. These results were consistent across mouse models of colon cancer the researchers studied, along with organoids—lab-grown ...