为优化枯草芽孢杆菌（Bacillus subtilis）纤维素酶生物合成，研究人员开展了调控胞内 NAD + /NADH 水平的研究。通过模块化工程策略筛选相关基因，发现共表达 ycel、nadV、nadM 和 mdh 可显著提升纤维素酶活性。该研究揭示了调控机制，为提升酶产量提供新途径。

研究结论表明，线粒体蛋白水平可能与先天性心脏、泌尿、神经系统、耳部和肢体畸形存在因果关系。这一发现突出了线粒体功能障碍在结构性出生缺陷发病机制中潜在的病因学作用。丙酮酸脱氢酶激酶同工酶 1 和 ATP 合酶 β 亚基线粒体水平降低与先天性心脏病风险降低相关，说明丙酮酸代谢和 ATP 生成过程的紊乱可能干扰心脏发育过程，导致心脏结构缺陷。39S 核糖体蛋白 L14 ...

As cells are infected by microorganisms, they can pre-emptively die to prevent the replication and spreading of the pathogen. Cell death that is associated with the presence of pathogen-associated ...

Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

MTT（3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide）法是一种经典的细胞增殖与细胞活性检测方法，基于线粒体内琥珀酸脱氢酶（succinate dehydrogenase）的活性 ... Cell Meter Intracellular NADH/NADPH Fluorescence Imaging Kit Red ...

While the first reaction step from CO 2 to formate is electrocatalytic, the second and third steps are catalyzed by formaldehyde dehydrogenase and alcohol dehydrogenase. These enzymes require NAD ...

School of Food Sciences and Engineering, South China University of Technology, Guangzhou, China In this study, we applied TurboID to explore the directly interacting proteins of cyanobacterial S2P. In ...

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China ...

Alcohol dehydrogenase and aldehyde dehydrogenase metabolise alcohol to acetaldehyde and subsequently to acetic acid in the mitochondria. These lead to the reduction of nicotinamide adenine ...

This is the first book that provides a comprehensive review of the entire area of artificial cells. The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has ...

cc.huji.ac.il AIM To determine whether vitamin K1, which is routinely administered to neonates, could act as an exogenous oxidising agent and be partly responsible for haemolysis in glucose-6-phosphat ...