The NADH produced from the reaction catalyzed by GAPDH can be transformed into NADPH in the cytoplasm through the pyruvate-oxaloacetate-malate cycle (POM cycle). The gapdh is traditionally used as a ...

Here they show that reduced pyruvate dehydrogenase (PDH) activity lowers locomotion but extends lifespan in daphnids and show that inhibition of PDH can increase lifespan in these species.