Autophagy is an intracellular process that targets various cargos for degradation, including members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double-stranded DNA and triggers ...

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

Plants mobilize the endomembrane system for restoring homeostasis when stimulated by stresses. Though the function of ufmylation in ER stress and autophagy has been described in mammals, their ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

This important study investigates the role of ATG6 in regulating NPR1, a key protein in the plant immune response. The authors present compelling evidence that ATG6 not only interacts with NPR1 in ...

Overexpression of constitutively active EZRIN T567D is sufficient to relocalize TSC complex to the endosomes and reactivate mTORC1. Our findings identify EZRIN as a critical regulator of autophagy via ...

Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India ...