F. Javier Rodríguez Baena, the first author of the article, explains, "We demonstrated that when we block Rela/NF-kB signaling in microglia, these cells begin to send signals to other immune ...
The final targets of TLRs are DNA-binding transcription factors (such as NF-kB and IRFs) that activate specific patterns of gene expression in the nucleus. The signaling system is conserved in the ...
We have identified a key signaling pathway, Rela/NF-kB, that, when blocked, reverses the protumoral function of microglia and activates an immune response against tumors." Berta Sánchez-Laorden ...
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