Twenty-six unrelated patients of African ancestry clinically suspected to have NF1 were recruited from Genetic clinics across the Gauteng province of South Africa and consented to participate in the ...

ESOM 和 CANA 调节 MTX 中毒大鼠的炎症反应：MTX 会增加肝脏中 p-p38 丝裂原活化蛋白激酶（p-p38MAPK）、磷酸化 c-Jun 氨基末端激酶（p-JNK）、磷酸化细胞外调节蛋白激酶 1（p-ERK1）、核因子 κB p65（NF-κB p65）、p-JAK1 和 p-STAT3 等蛋白的表达水平，同时提高白细胞介素 1β ...

研究人员采用了多种关键技术方法。首先构建了结直肠癌原位小鼠模型，通过向小鼠盲肠注射 CT26 - GFP ...

肿瘤浸润调节性T细胞（Tumor-infiltrating regulatory T cells，TI-Treg cells）是肿瘤微环境中抑制抗肿瘤免疫并促进肿瘤进展的关键免疫细胞。尽管已有多种疗法旨在靶向TI-Treg细胞，然而大多数治疗效果不佳 ...

The following article reviews previous studies on cell death regulation in IEC and a potential role of necroptosis for gut homeostasis. Another important regulator of epithelial cell death is Stat3.