Furthermore, EGT was observed to reverse the LPS induced increase in the ratio of M1 to M2 macrophages. EGT was also observed to markedly suppress the LPS-induced phosphorylation of JAK/STAT3 and ...

Twenty-six unrelated patients of African ancestry clinically suspected to have NF1 were recruited from Genetic clinics across the Gauteng province of South Africa and consented to participate in the ...

"In the amygdala, the gene Stat3 is involved in the regulation of blood pressure and possibly plays a role in blood pressure elevation in response to chronic stress. It might also be involved in ...

西安交通大学第一附属医院的研究人员勇挑重担，开展了一项关于前列腺癌的深入研究。他们将目光聚焦在钙调节热稳定蛋白 1（CARHSP1）上，试图揭开它在前列腺癌发生发展过程中的神秘面纱。研究发现，CARHSP1 在前列腺癌中高表达，并且与前列腺癌的晚期特征以及患者的不良预后密切相关。进一步研究揭示，CARHSP1 作为一种 RNA 结合蛋白（RBP），能够通过增强白细胞介素 17 受体 A（IL-17 ...

为探究 1 型神经纤维瘤病（NF1）正常组织中是否存在 “二次打击”，英国研究人员开展测序研究，发现 NF1 在正常组织中有二次突变且受正选择，有助于理解该疾病癌症表型。 一、研究背景 在生命的微观世界里，癌症的发生机制一直是科学家们努力探索的谜题。

2月25日，中山大学研究团队在期刊《Cell Death&Disease》上发表了研究论文，题为“Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in ...

This pipeline is for processing the NF1 organoid data. More documentation to come soon.

CAMBRIDGE, England--(BUSINESS WIRE)--Healx, an AI-enabled, clinical-stage biotech company dedicated to rare diseases, today announced the first patient has been dosed in INSPIRE-NF1, a Phase 2 ...

The US Food and Drug Administration has approved mirdametinib for the treatment of neurofibromatosis type 1 (NF1) in adults and children. The drug, developed by SpringWorks Therapeutics , is the first ...

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