While Notch is thought to exert the majority of its effects through transcriptional activation of Myc, it also likely has independent roles in T-ALL malignancy. Here, we utilized a zebrafish ...

MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular ...

It’s easy to get excited about the second annual Minnesota Yacht Club coming to St. Paul’s Harriet Island on July 18-20. With ...

Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

PI3K [51–54] PI3K PI3Ki Breast Notch, Myc, MET [57–59] BCR–ABL Imatinib, nilotinib CML Secondary BCR–ABL mutations, BCR–ABL amplification, P-glycoprotein, MDR, LYN [65–69] KIT Imatinib ...

M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation When Maralice ...

Figure 1: Transgene expression and phenotype. Figure 2: K14.MYC2 mice exhibit impairment in wound healing. Figure 3: K14.MYC2 primary keratinocytes exhibit a defect in migration. Figure 4: K14 ...

When Foran shone blue light onto cells with the receptors he had engineered, the Notch receptor was freed from the plasma membrane and moved into the cell nucleus, where it resulted in changes in gene ...