Mechanistic investigations revealed that Met activates the AMPK/Nrf2 pathway, effectively preventing ferroptosis progression. Additionally, in vivo results demonstrated Met alleviates bone loss and ...

ChIP-qPCR results confirmed that Nrf2 directly binds to the GGTLC2 promoter region to regulate its expression, and crocin attenuated this binding interaction. Discussion: In conclusion, our findings ...

Department of Health Management of the Guangdong Second Provincial General Hospital & Postdoctoral Research Station of Basic Medicine of the School of Medicine; Department of Bioscience and ...

Mechanism studies have shown that FTL promotes ESCC development and metastasis via NRF2 pathway and inhibits ferroptosis via NCOA4/FTH1/HMOX1 axis (IDDF2024-ABS-0075 Figure 3. FTL promotes ESCC ...

国家癌症中心最新数据显示，我国每年新发恶性肿瘤病例超450万例，治疗期间超过80%患者存在营养认知误区。在临床治疗技术突飞猛进的今天，膳食营养支持已成为国际肿瘤学界关注的新焦点。本文基于《中国肿瘤营养治疗指南》核心框架，结合美国癌症研究院（AICR）最新研究成果，系统解析水果抗癌机制的科学依据与实操要点。

胰腺癌死亡率高、治疗手段有限，新兴的生酮饮食或可通过铁死亡（ferroptosis）辅助治疗，但机制不明。研究人员开展胰腺癌生酮代谢与铁死亡分子机制研究，发现 CAV1 是关键分子，多层面调控轴揭示了生酮饮食诱导铁死亡机制，为胰腺癌辅助治疗提供潜在靶点。

该研究揭示了肠道微生物群失调与AD病理之间的密切关联，并通过多种实验验证了肠道微生物群调控Aβ沉积和改善认知功能的潜力。这为粪菌移植（FMT）在AD治疗中的应用提供了重要理论依据和研究方向。未来，FMT可进一步优化为特定菌群的靶向移植，例如富集拟杆菌 ...

推荐阅读：本文聚焦 HNSCC 中 ferroptosis，阐述其分子机制与治疗策略，极具科研价值。 头颈部鳞状细胞癌（HNSCC）中 ferroptosis 的分子机制及治疗研究进展 一、ferroptosis 概述 ferroptosis 是一种受调控的、依赖铁的细胞死亡方式，脂质过氧化和线粒体功能障碍在其中 ...

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...