The paper by Gao et al. describes the effect of capsaicin on the NRF2/KEAP1 pathway. The authors carried out a set of in vitro and in vivo experiments that addressed the mechanisms of the protective ...
This important study suggests that capsaicin nanoparticle administration in rats activates the transcription factor Nrf2 by directly binding to its repressor KEAP1, leading to cytoprotective gene ...
This leads to a localized inflammatory response, potentially contributing to the disruption of the BTB and an imbalance between oxidative and antioxidant systems, such as the NRF2-KEAP1 pathway and ...
Cell. 2012. Vol. 149:1060–1072 Zhang M, Zhang T, Song C, Qu J, Gu Y, Liu S, et al.. Guizhi Fuling Capsule Ameliorates Endometrial Hyperplasia through Promoting p62-Keap1-NRF2-mediated Ferroptosis.
As a crucial cellular process involved in degrading and recycling damaged organelles and proteins, autophagy-related (ATG) proteins mediated autophagy plays a significant role in various physiological ...
来源于骨髓、脂肪及新生儿脐带和胎盘等的间充质干细胞(mesenchymal stem cells, MSC)具有强大的增殖能力和多能性,能够分化为脂肪细胞、骨细胞和软骨细胞等中胚层谱系,神经细胞等外胚层谱系,以及肝细胞等内胚层谱系。Friedenstein等人于1966年首次发现其多能性。
Chulabhorn International College of Medicine, Thammasat University, Pathumthani 10120, Thailand Department of Basic Medical Sciences, Faculty of Medicine, Siam University, Bangkok 10160, Thailand ...
DMPE-PEG-Fluorescein 是一种结合了二肉豆蔻酰基磷脂(DMPE)、聚乙二醇(PEG)和荧光素(Fluorescein)的多功能磷脂衍生物。其结构特点如下: DMPE:提供疏水性,能够与细胞膜或脂质体相互作用,增强分子的膜亲和性。 PEG:赋予分子良好的水溶性和生物相容性,减少 ...
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