Moffitt Cancer Center, Tampa, FL. Search for other works by this author on: ...

Bayer and Vividion Therapeutics to present latest research on their advancing oncology portfolio at AACR 2025 annual meeting: Berlin, Germany Wednesday, April 23, 2025, 10:00 Hrs ...

在体内，当机体因运动等因素产生疲劳时，会伴随氧化应激增加和能量代谢紊乱等现象 。YPLP 可激活 Nrf2/Keap1 信号通路，Nrf2 是一种重要的转录因子，在正常状态下，它与 Keap1 结合并处于失活状态 。当受到外界刺激，如 YPLP 的作用时，Nrf2 与 Keap1 解离并进入细胞 ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Figure 1: Representative images of the induction of autophagy and the outcome of its suppression. Figure 2: The role of autophagy in development and differentiation in mammals.

Central to this breakthrough is Nuclear factor E2-related factor 2 (Nrf2), a transcription factor now recognized as a pivotal player in chemoradiotherapy resistance. Traditionally acknowledged for ...

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Image Caption: Mechanisms of resistance to chemoradiotherapy in osteosarcoma. In chemoradiotherapy resistant OS cells, altered expression of the drug transporter proteins, RFC and ABC family ...

本文聚焦于转录因子 NRF2，探讨其与乙酰化酶 / 去乙酰化酶（主要是 SIRT1）的相互作用。研究发现二者存在复杂关系，或形成正反馈回路，同时还涉及通过其他信号通路的间接作用。这些成果为深入理解细胞保护机制提供了新视角。 NRF2 转录因子的重要作用 转录 ...