Zhang D D. The Nrf2-Keap1 pathway in oxidative stress. Free Radic Biol Med. 2006;40(5):604 - 616. This review article comprehensively introduced the Nrf2 - Keap1 pathway, providing a theoretical basis ...

Department of Ophthalmology, Tongji Hospital Affiliated with Tongji University, Shanghai 200065, People’s Republic of China ...

你知道吗？在细胞内，有一种名为Nrf2的蛋白质，它可是我们身体对抗氧化应激的一线战士。但有时候，这个战士会被另一个叫做Keap1的蛋白给束缚住，导致抗氧化能力下降。那么有没有办法让Nrf2重新活跃起来呢？今天咱们就聊聊一种叫做Keap1-Nrf2-IN-16的小分子 ...

A new study suggests genetic changes allow horses to produce more energy, while minimizing the toll the energy takes on cells.

此外，还观察到胆碱酯酶活性下降和组织架构改变。通过 qRT - PCR 分析 mRNA 表达发现，与抗氧化防御相关的基因（SIRT1、Nrf2、HO - 1、NQO1）上调，同时细胞凋亡标志物半胱天冬酶 - 8（caspase - 8）和半胱天冬酶 - 3（caspase - 3）下调。该研究突出了 CoQ10、BCA 和 PHL 通过 ...

编辑推荐：针对胃癌化疗耐药难题，南昌大学第一附属医院团队揭示TMEM160通过招募E3连接酶TRIM37促进KEAP1的K48泛素化降解 ...

The changes occurred in a key gene pathway called NRF2/KEAP1. The pathway senses the buildup of oxidative stress and then kickstarts antioxidant production, which can clean it up, said Castiglione.

Acacetin can also activate the MsrA-Nrf2/Keap1 pathway to enhance cellular antioxidant capacity, ultimately reducing ox-LDL-induced endothelial cell apoptosis. Additionally, acacetin can activate the ...