"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...

Risk of vascular event † Pharmacological strategies Low (<1% per year) tNSAID or coxib depending on GI risk Intermediate (1–3% per year) tNSAID (low-dose ibuprofen or naproxen + PPI); if ...