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The study proposes that selective loss of DNA methylation at a subset of promoters is required for nucleosome retention and the establishment of epigenetic states that may influence embryonic gene ...

The epigenetic memory of a cell defines the set of modifications to the cell's deoxyribonucleic acid (DNA) that do not alter the DNA sequence, and have been inherited from the cell from which it ...

Open Source, Automated free binding free energy calculation between protein and small molecule. An all-in-one workflow, free energy pertubation with OpenMM.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Locusts, as devastating pests, can reversibly ...

The chimera includes a portion of CDEII and all of CDEIII from the native centromere to allow for DNA-dependent binding between the nucleosome core particles (NCPs) and the kinetochore, as well as ...

Indeed, upon transcriptional inhibition, ADPr condensates were no longer observed (Fig. 1B). Because PARP14 was pulled down by ADP-ribose binding Af1521 macrodomain following IFNγ treatment in ...

核心组蛋白是DNA的重要“包装材料”，它们与DNA结合形成核小体（nucleosome），进一步组装成染色质。染色质的结构状态直接影响基因的转录 ...