Scientists at St. Jude Children’s Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to chromatin remodeling, a process implicated in cancer and developmental ...

The cell's genetic material, DNA, is packaged into tightly wound structures called nucleosomes. The DNA (red) is wound around two sets of core histone proteins (green) to form a kind of bead on a ...

A study by scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) introduces a more cost-effective, scalable ...

A nucleosome core particle consists of eight ... in that it gives eukaryotic cells the capability to exert complex levels of control over gene expression. As described throughout this article ...

So how does the cell know where to uncoil in a process called chromatin remodeling? As previously mentioned, chromatin is remodeled (and thus, nucleosome structure is altered) primarily through ...

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This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

The chip that is inserted into the 10X Genomics software, allowing researchers to analyze DNA and RNA simultaneously.

To date, potent, selective and cell-active NSD2 inhibitors have not been described. A platform was established for the discovery of selective NSD2 inhibitors from quantitative high-throughput ...

One chromatin remodeling mechanism called "nucleosome sliding" allows a nucleosome ... information inside the nucleus of the eukaryotic cell. Chromatin remodelers help the cell access and ...