果糖 - 1,6 - 二磷酸酶 1（FBP1）作为糖异生过程中的一种限速酶，在肿瘤的发展过程中也起着关键作用。已有研究表明，FBP1 在许多恶性肿瘤中表达下调，且与患者预后不良相关。然而，在缺氧环境下，FBP1 的翻译后调控机制仍然是一个未解之谜。这就好比在黑暗中摸索，我们知道 FBP1 ...

射血分数保留的心力衰竭（HFpEF）发病机制不明。研究人员开展 HFpEF 小鼠模型研究，发现内皮细胞中己糖激酶 1（HK1）线粒体结合对蛋白 O-GlcNAcylation 和 HFpEF 发展关键。该研究揭示新机制并提供潜在疗法。 射血分数保留的心力衰竭（HFpEF）是全球范围内导致发病 ...

Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

糖尿病患者即使血糖得到良好控制，仍面临心力衰竭的高风险。这种现象被称为 “代谢记忆”或 “高血糖记忆”，即高血糖对血管的长期负面影响，即使血糖恢复正常后仍存在。 2025年4月2日， 西安交通大学、 第四军医大学等研究人员在" Cell ...

O General 2 Ton 3 Star Split AC (24FUTC) ₹ 74,500 O General 1.5 Ton 5 Star Inverter Split AC (ASGG18CGTA) ₹ 67,550 O General 2 Ton 5 Star Inverter Split AC (ASGG24CGTA) ₹ 69,990 O General 1 Ton 5 Star ...

Realty Income (NYSE: O), an S&P 500 company, is real estate partner to the world's leading companies. Founded in 1969, we invest in diversified commercial real estate and, as of December 31 ...

King Charles III and Queen Camilla paid a private visit to Pope Francis in the Vatican on the afternoon of April 9, the 18th day of his convalescence.

O Fountain of Life, unfathomable Divine Mercy, cover the whole world and empty yourself out upon us. O Blood and Water which gushed forth from the heart of Jesus as a Fountain of Mercy for us ...

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...