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23 天
赭曲霉毒素 A 通过促进糖酵解诱导线粒体途径凋亡和铁死亡:揭示肾 ...
为探究赭曲霉毒素 A(OTA)肾毒性是否经代谢重编程介导,研究人员开展了 OTA 和 / 或 2 - 脱氧 - D - 葡萄糖(2-DG)对人近端肾小管上皮(HK-2)细胞影响的研究。结果表明 OTA 可诱导细胞凋亡和铁死亡并促进糖酵解,该研究首次揭示此机制。 赭曲霉毒素 A(OTA)是 ...
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