1 Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, Bone and Joint Research Group, University of Liverpool, Liverpool, UK 2 Lancaster Medical School, Faculty of Health & ...

There are two types of clubbed fingers, nails, or toes with one type typically being a sign of severe disease. Primary (idiopathic) clubbing, also called hypertrophic osteoarthropathy (HOA), is ...

为解决原发性肥厚性骨关节病（PHO）因罕见导致的误诊、漏诊问题，研究人员开展了对 HPGD 变异相关 PHO 的研究。通过对 2 例儿科 PHO 病例的临床和基因分析及文献回顾，发现新变异，明确常见变异类型。这对早期诊断和多学科管理意义重大。 该研究报告了一种新的 HPGD 基因变异 c.189C>A，这一发现大大扩展了 PHO 的已知变异谱。同时，明确了 c.310_311delCT 变异是 ...

Rehabilitation after knee surgery typically lasts about 12 weeks. But many people can walk without an assistive device after 3 weeks and drive after 4–6 weeks. After total knee replacement (TKR ...

该研究强调了识别 PHO 特征的重要性。 原发性肥厚性骨关节病（Primary hypertrophic osteoarthropathy，PHO）是一种罕见的全身性疾病，其特征为骨膜新骨形成、手指和脚趾杵状膨大，以及皮肤增厚，尤其是额头和面部。本案例研究介绍了一名 24 岁男性患者，他有长达十 ...

Background: Dysthyroid optic neuropathy (DON), the most severe complication of thyroid eye disease (TED), has unclear mechanisms and unsatisfactory treatment outcomes. This study aimed to identify key ...

Finally, osteoarthropathy can be caused by continuous aggregation of β (2)-microglobulin; therefore, can we develop β (2)-microglobulin amyloid osteoarthropathy in experimental animals by local ...