为探究砷（As）对鲤鱼脾脏的毒性机制以及锌（Zn）是否能通过 P38 MAPK/Nrf2/HO-1 通路缓解 As 诱导的氧化应激和炎症损伤，研究人员开展相关研究。结果发现 Zn 可减轻 As 诱导的脾脏损伤，这为 Zn 的解毒机制及在水产养殖中减轻重金属毒性提供了新见解。 砷（As ...

JNK/p38 MAPK的协同调控 磷酸化抗体检测发现WD同步激活JNK和p38 MAPK，双通路抑制剂联用比单抑制剂更显著降低凋亡率（p<0.01）。图4A展示通路蛋白表达变化，但被质疑与图3A存在图像重叠。 体内外实验验证治疗潜力 小鼠异种移植模型中，WD组肿瘤体积减少70% ...

Piezo1 通道激活后 3 小时，IL-6 免疫反应性也显著增加。这些数据证实，Piezo1 激活上调大鼠结膜上皮中的 p-p38 MAPK、p-CREB 和 IL-6水平，与体外培养的 HConjECs 现象相似。 此外，还观察到大鼠结膜上皮中 Piezo1 受体刺激后 24 小时，中性粒细胞、髓过氧化物酶（MPO ...

The anti-melanogenesis effect of ligustroside derived from Ligustrum japonicum and its underlying mechanisms are explored.

Department of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research ...

IPC Indice de Precios Y Cotizaciones 50,413.40-1,039.33-2.02% ...

IPC Indice de Precios Y Cotizaciones 51,452.73-2,636.55-4.87% ...

The S&P 500 fell 4.6% during the first quarter of 2025, ending a streak of five consecutive quarterly gains and marking its worst quarter since 2022. Track all markets on TradingView As the ...

U.S. President Donald Trump has made numerous tariff threats since returning to office on January 20, ranging from a universal duty on imports to targeted tariffs on specific sectors or countries ...

Stock market today: S&P 500 rallies on hopes for softer tariffs By Investing.com - Mar 24, 2025 90 Investing.com-- The S&P 500 closed sharply higher Monday, led by tech as sentiment was boosted by ...