为探究砷（As）对鲤鱼脾脏的毒性机制以及锌（Zn）是否能通过 P38 MAPK/Nrf2/HO-1 通路缓解 As 诱导的氧化应激和炎症损伤，研究人员开展相关研究。结果发现 Zn 可减轻 As 诱导的脾脏损伤，这为 Zn 的解毒机制及在水产养殖中减轻重金属毒性提供了新见解。 砷（As ...

One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.