抑制 mTOR 信号通路减轻颗粒细胞损伤：使用 mTORC1 抑制剂依维莫司（RAD001）处理培养的小鼠颗粒细胞，发现 p - Rps6 表达降低，γ - H2AX 阳性颗粒细胞比例减少，表明 mTOR 抑制对 DNA 损伤和细胞凋亡有保护作用。在体内实验中，注射 RAD001 和 CTX 的小鼠，其颗粒细胞中 ...

乳腺癌是女性中最常见的癌症类型，全球每年确诊超过200万例，2020年中国的新发病例约42万，HR+乳腺癌亚型约占所有乳腺癌的70%，患者基数十分庞大。PIK3CA突变是乳腺癌的重要驱动基因之一，在乳腺癌中占30%-40%，中国乳腺癌患者PIK3CA ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

Promising therapies for platinum-resistant ovarian cancer produced mixed results in separate trials. The AKT inhibitor ...

近日，中国国家药品监督管理局（NMPA）正式批准伊那利塞片联合哌柏西利和氟维司群，适用于内分泌治疗耐药（包括在辅助内分泌治疗期间或之后出现复发）、PIK3CA突变、激素受体（HR）阳性、人表皮生长因子受体2（HER2）阴性的局部晚期或转移性乳腺癌成人患者。

Metastatic breast cancer is complex, requiring holistic care and ongoing treatment, with varying prognosis depending on ...

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PR+ breast cancer responds well to hormone therapy, underscoring the need for molecular insight and targeted treatment ...

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