抑制 mTOR 信号通路减轻颗粒细胞损伤：使用 mTORC1 抑制剂依维莫司（RAD001）处理培养的小鼠颗粒细胞，发现 p - Rps6 表达降低，γ - H2AX 阳性颗粒细胞比例减少，表明 mTOR 抑制对 DNA 损伤和细胞凋亡有保护作用。在体内实验中，注射 RAD001 和 CTX 的小鼠，其颗粒细胞中 ...

乳腺癌是女性中最常见的癌症类型，全球每年确诊超过200万例，2020年中国的新发病例约42万，HR+乳腺癌亚型约占所有乳腺癌的70%，患者基数十分庞大。PIK3CA突变是乳腺癌的重要驱动基因之一，在乳腺癌中占30%-40%，中国乳腺癌患者PIK3CA ...

Promising therapies for platinum-resistant ovarian cancer produced mixed results in separate trials. The AKT inhibitor ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

近日，中国国家药品监督管理局（NMPA）正式批准伊那利塞片联合哌柏西利和氟维司群，适用于内分泌治疗耐药（包括在辅助内分泌治疗期间或之后出现复发）、PIK3CA突变、激素受体（HR）阳性、人表皮生长因子受体2（HER2）阴性的局部晚期或转移性乳腺癌成人患者。

Metastatic breast cancer is complex, requiring holistic care and ongoing treatment, with varying prognosis depending on ...

DAX Futures 23110.00 162.00 0.71% ...

Your FREE insider update on the biggest news stories and investing trends, delivered midday TheChart of the Day belongs to ...

PR+ breast cancer responds well to hormone therapy, underscoring the need for molecular insight and targeted treatment ...

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.