抑制 mTOR 信号通路减轻颗粒细胞损伤：使用 mTORC1 抑制剂依维莫司（RAD001）处理培养的小鼠颗粒细胞，发现 p - Rps6 表达降低，γ - H2AX 阳性颗粒细胞比例减少，表明 mTOR 抑制对 DNA 损伤和细胞凋亡有保护作用。在体内实验中，注射 RAD001 和 CTX 的小鼠，其颗粒细胞中 ...

Background: Diabetes mellitus (DM) is a metabolic disease with high morbidity, which significantly affects human life and health expenditures. Previous studies have demonstrated that artemether (ATM) ...

Owing to its high mortality rate, lung cancer (LC) remains the most common cancer worldwide, with the highest malignancy diagnosis rate. The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) ...

International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, 182 min-Zu Road, Wuhan 430074 ...

乳腺癌是女性中最常见的癌症类型，全球每年确诊超过200万例，2020年中国的新发病例约42万，HR+乳腺癌亚型约占所有乳腺癌的70%，患者基数十分庞大。PIK3CA突变是乳腺癌的重要驱动基因之一，在乳腺癌中占30%-40%，中国乳腺癌患者PIK3CA ...

Promising therapies for platinum-resistant ovarian cancer produced mixed results in separate trials. The AKT inhibitor ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

a target of mTOR and activation of LC3, a main marker of autophagy. The severity of cartilage degradation was significantly (p<0.01) reduced in the rapamycin-treated group compared with the control ...

In NPC1 cells, SFN induces TFEB nuclear translocation via a ROS-Ca 2+-calcineurin dependent but MTOR-independent pathway and upregulates the expression of TFEB-downstream genes, promoting lysosomal ...