Here the authors show that in response to bile acid chenodeoxycholic acid during cholestasis, endothelial Myc activation triggers P-selectin expression, promoting neutrophil infiltration and liver ...

由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引发的新冠肺炎（COVID-19），常常会使患者出现血栓性并发症。P - 选择素（P-selectin）作为关键的血小板标志物，在血小板与白细胞聚集过程中发挥核心作用，对止血和血栓形成意义重大。此外，D - 二聚体（D-dimer ...

面对这一突破性发现，临床转化仍面临三重挑战。首先，血小板介导的免疫抑制具有动态波动性，现有检测技术难以实时捕捉CTC-血小板复合体；其次，CD155在神经系统中的生理功能可能带来治疗副作用；再者，肿瘤细胞可通过上调CD96受体实现补偿逃逸。针对这些瓶颈，研究团队提出开发双特异性抗体同时阻断TIGIT/CD96通路，并结合液态活检技术动态监测治疗效果。

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Umut A. Gurkan is leading the CASE Biomanufacturing and Microfabrication Laboratory (CASE-BML). Dr. Gurkan’s research is focused on microcirculation, vascular biology, red blood cells, hemoglobin, ...

Figure. Overview of current and in development antiplatelet agents. COX-1 indicates cyclooxygenase-1; GPVI, glycoprotein VI; PAR1, protease-activated receptor-1; PDE, phosphodiesterase; PDI, protein ...

BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

Henan Key Laboratory of Nanomedicine for Targeting Diagnosis and Treatment, Zhengzhou 450001, China ...