Several pieces of evidence indicate that the tumour suppressor p27 (encoded by CDKN1B) has other functions beyond its role as a cell-cycle inhibitor. James Roberts, Arnaud Besson and colleagues ...

Failure to control the cell cycle adequately can lead to diverse life-threatening diseases such as cancer. Figure 2: Deregulation of p27 protein turnover contributes to tumorigenesis.

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...