Several pieces of evidence indicate that the tumour suppressor p27 (encoded by CDKN1B) has other functions beyond its role as a cell-cycle inhibitor. James Roberts, Arnaud Besson and colleagues ...

Failure to control the cell cycle adequately can lead to diverse life-threatening diseases such as cancer. Figure 2: Deregulation of p27 protein turnover contributes to tumorigenesis.

They began producing well-known markers of maturation such as CD38 and CD11b, generated reactive oxygen species (ROS), and expressed the inhibitor of the cell cycle, p27, all signs that the cells ...