在这样的背景下，来自多个研究机构的研究人员决定携手探索解决之道。他们聚焦于羧基末端热休克蛋白 70 相互作用蛋白（CHIP），试图弄清楚它在高血糖环境下对 MSCs 功能的影响。经过一系列深入研究，他们发现了一个令人振奋的结果：CHIP 能够促进高糖诱导的 p53 发生泛素化并通过蛋白酶体降解，从而有效维持 WJMSCs 的自我更新能力。这一发现意义重大，为治疗糖尿病相关并发症提供了全新的潜在策略 ...

滑膜肉瘤（SS）治疗手段有限、预后差。研究人员开展 WDR5 在 SS 中作用的研究。结果发现 WDR5 是 SS 的 “表观” 依赖，靶向降解 WDR5 可抑制 SS 生长。这为 SS 治疗提供新策略，有望改善患者预后。

Fraunhofer’s researchers investigated the common methods used to test for UV degradation and found that they can overstate the extent of the issue compared to what is experienced in the field.

Abstract: The construction of a digital twin model for the full life cycle of rolling bearings is of great significance for analyzing their degradation performance and health management. However, ...

The result – surprising at first glance – is that conventional UV tests can significantly exaggerate the degradation effect. In these lab tests, experts simulate the natural UV exposure ...

Our results showed that KT-253 degrades MDM2 with subnanomolar potency [half maximal degradation concentration (DC 50) = 0.4 nmol/L], whereas SMI DS-3032 treatment upregulated MDM2 (Fig. 1C). KT-253, ...

5Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, ...

Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% of the global population at some point in their lifetime. A team of ...

March 6, 2024: ION Storage Systems‘ anodeless and compressionless solid-state batteries successfully achieved and exceeded 125 cycles with less than 5% capacity degradation in performance.